Observational studies have shown that concomitant use of opioid analgesics and benzodiazepines raises the possibility of drug-associated mortality when compared with utilization of opioids on your own. If a decision is made to prescribe Valium concomitantly with opioids, prescribe the lowest effective dosages and bare minimum durations of concomitant use, and adhere to sufferers intently for signs and indicators of respiratory melancholy and sedation.
Use Caution/Watch. Ethinyl estradiol could inhibit the clearance of benzodiazepines that bear oxidation, therefore expanding serum concentrations of concomitantly administered benzodiazepines.
phenobarbital will decrease the level or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
sparsentan will reduce the extent or outcome of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Check. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and decreases efficacy connected with these substrates.
Prevent or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or swap with alternate therapies. If coadministration is unavoidable, observe individuals for lack of therapeutic outcome of such medications.
Indicated for acute remedy of intermittent, stereotypic episodes of Recurrent seizure action (ie, seizure clusters, acute repetitive seizures) distinct from a individual’s usual seizure pattern Employed adjunctively in convulsive Diseases, although it hasn't proved helpful as the only therapy
fedratinib will enhance the amount or impact of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Adjust dose of drugs that are CYP2C19 substrates as required.
Coadministration of other CNS depressants or Alcoholic more info beverages intake might potentiate CNS-depressant consequences of diazepam
Insignificant alterations in EEG designs, generally reduced-voltage quickly activity, have been noticed in sufferers all through and immediately after diazepam therapy and they are of no recognised importance
Diazepam is N-demethylated by CYP3A4 and 2C19 to your Energetic metabolite N-desmethyldiazepam, and it is hydroxylated by CYP3A4 into the Energetic metabolite temazepam. N-desmethyldiazepam and temazepam are each further more metabolized to oxazepam. Temazepam and oxazepam are mainly removed by glucuronidation.
hydrocortisone will reduce the extent or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Steer clear of concomitant use of tucatinib with CYP3A substrates, in which minimal focus modifications may possibly bring about serious or daily life-threatening toxicities. If unavoidable, reduce CYP3A substrate dose As outlined by solution labeling.
diazepam will enhance the level or result of flibanserin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Improved flibanserin adverse consequences may possibly come about if coadministered with various weak CYP3A4 inhibitors.
Energetic metabolites: N-desmethyldiazepam and temazepam, which can be the two further metabolized to oxazepam; largely removed by glucuronidation